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Talphera, Inc. (TLPH) Stock Analysis

Healthcare

Talphera, Inc.

$0.80

$-0.02 (-1.85%)

Last Updated: May 26, 2026

Price History

Analysis

Company Overview

Talphera, Inc. operates as a specialty pharmaceutical company dedicated to the development and commercialization of therapies intended for use within medically supervised settings. The firm functions within the broader Healthcare sector, specifically classified under the industry of Drug Manufacturers - Specialty & Generic, which implies a focus on niche therapeutic areas and often smaller-scale production compared to broad-spectrum manufacturers. The company currently maintains a market capitalization of $37.11M, while its annual revenue for the trailing twelve months stands at $28,000. The employee count is listed as N/A in available data, indicating that specific headcount details are not currently disclosed for public reporting. These financial figures highlight the company's position as a micro-cap entity with minimal revenue generation relative to its market valuation, suggesting a capital-intensive development phase where the market capitalization significantly exceeds the revenue base, a common characteristic for firms investing heavily in research and development prior to commercial product launch.

Financial Health

The financial statements for Talphera, Inc. reveal a trailing twelve-month revenue of $28,000, a net income of $-14,363,000, and an EBITDA metric that is not available due to the company's reporting status. The substantial gap between the negligible revenue of $28,000 and the net loss of $-14,363,000 indicates a cost structure dominated by high operating expenses, likely driven by research and development activities or clinical trial costs that far outpace current sales. The company reports a free cash flow of $-6,531,500, which signifies a continuous burn rate where cash outflows for operations and capital expenditures exceed cash inflows, limiting immediate financial flexibility without external financing. Margin analysis shows a gross margin of 0.0%, an operating margin of -48157.1%, and a profit margin of 0.0%, reflecting that the company is not yet profitable on a per-unit basis and is operating at a significant loss before interest, taxes, and non-recurring items. Regarding leverage, the company holds $20.38M in cash against $6.50M in debt, resulting in a debt-to-equity ratio of 38.15, which suggests a balance sheet that is currently net cash positive despite the high debt-to-equity multiple often seen in early-stage biotech firms. The current ratio stands at 5.49, indicating a robust short-term liquidity position where current assets significantly exceed current liabilities, providing a wide buffer against short-term obligations. Return metrics show a return on equity of -114.7% and a return on assets of -35.1%, revealing that management is currently destroying value from the perspective of shareholders and total assets due to the net loss position rather than generating returns on the capital base.

Valuation Assessment

Valuation metrics for Talphera, Inc. present a complex picture with a trailing P/E ratio of N/A and a forward P/E of -2.65. The discrepancy between the unavailable trailing P/E and the negative forward P/E implies that the company does not yet generate positive earnings, and the forward metric reflects expectations of potential future earnings per share that have not yet materialized in historical data. The price-to-book ratio is recorded at 2.15, indicating that the market values the company at a premium of over double its net book value, a valuation often seen in biotech firms where intangible assets and pipeline potential are priced higher than tangible assets. Alternative valuation metrics include a price-to-sales ratio of 1325.43 and an EV/EBITDA of N/A, suggesting that traditional earnings-based valuation models are inapplicable and that investors are pricing the stock based on pipeline potential and sales multiples rather than current profitability. The stock trades within a specific range with a 52-week high of $1.57 and a 52-week low of $0.38. Without a specific current price provided in the facts to calculate an exact percentage, the valuation relative to this range is determined by these established high and low points which define the recent volatility boundaries for the security. The beta value is 0.49, indicating that the stock's price volatility is less than half that of the broader market, suggesting a lower sensitivity to general market movements compared to large-cap equities.

Growth & Income

Growth metrics for Talphera, Inc. show revenue growth year-over-year as N/A and earnings growth year-over-year as N/A, as the company does not report comparable prior-year data in the provided financials. The inability to calculate year-over-year growth rates implies that the company is in an early stage of commercialization where historical growth trajectories have not yet been established for standard analysis. As a non-dividend payer, the company reports a dividend yield of N/A and a payout ratio of 0.0%, indicating that all available earnings, or rather the retention of capital, are directed back into the business operations and development pipeline rather than distributed to shareholders. Consequently, the overall growth and income profile for Talphera, Inc. is characterized by zero current income distribution and a reliance on capital markets to fund growth initiatives in the absence of organic profitability or dividend generation.

Peer Comparison

Talphera, Inc. (TLPH) operates in the Drug Manufacturers - Specialty & Generic industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Talphera, Inc. TLPH $41.52M N/A
Takeda Pharmaceutical Company Limited TAK $50.14B 41.8
Haleon plc HLN $40.92B 18.5
Teva Pharmaceutical Industries Limited TEVA $40.30B 25.8

The Drug Manufacturers - Specialty & Generic industry average P/E ratio is 47.5x. Talphera, Inc. trades at a P/E of N/A.

This analysis is AI-generated for informational purposes only and should not be considered financial advice. Data may be delayed or inaccurate. Always do your own research and consult a qualified financial advisor before making investment decisions.

About Talphera, Inc.

Talphera, Inc., a specialty pharmaceutical company, focuses on the development and commercialization of therapies for use in medically supervised settings. The company's lead product candidate, Niyad, is a lyophilized formulation of nafamostat that acts as a regional anticoagulant for infusion into the extracorporeal circuit. It is also developing LTX-608, a lyophilized vial containing nafamostat for IV infusion for disseminated intravascular coagulation, acute respiratory distress syndrome, acute pancreatitis, and an anti-viral treatment; Fedsyra, an ephedrine pre-filled syringe for injection; and a phenylephrine pre-filled syringe for injection. The company was formerly known as AcelRx Pharmaceuticals, Inc. and changed its name to Talphera, Inc. in January 2024. The company was incorporated in 2005 and is headquartered in San Mateo, California.

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Key Statistics

Market Cap
$41.52M
P/E Ratio
N/A
52-Week High
$1.57
52-Week Low
$0.38
Avg Volume
164.92K

Data provided by Yahoo Finance via yfinance. Updated daily.

Company Info

Exchange
NASDAQ
Country
United States
Employees
12