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NASDAQ · Biotechnology · USD

Sionna Therapeutics, Inc. (SION) Stock Analysis

Sionna Therapeutics, Inc. (SION) is a Biotechnology stock listed on NASDAQ and quoted in US Dollar.

Last Updated: October 21, 2026

SION

$3.87

−$0.28 (−6.75%)

Oct 21, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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SION Key Statistics

As of Oct 21, 2026
Trading
Open
$4.20
Previous Close
$4.15
Day's Range
3.86–4.31
52-Week Range
3.78–54.97
Volume
1.56M
Valuation
Market Cap
$174.73M
P/E Ratio
unprofitable
EPS (ttm)Profit attributable to each share over the last twelve months.
−2.16
Financials (FY)
Revenue (FY)
$0.00
Net Income (FY)
−$75.27M
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
45.15M
1-Year Return
−90.89%
Dividend and dates
Earnings Date
November 5, 2026estimated
Avg Volume
2.24M

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

Key facts

As of October 21, 2026, SION closed at $3.87, −90.89% over 1 year.

Sionna Therapeutics, Inc. (SION) has a market capitalization of $174.73M.

In fiscal 2025, SION reported revenue of $0.00.

SION Stock Return by Calendar Year

Sionna Therapeutics, Inc. (SION) return since Feb 2025: what $10,000 became

1 year
$10,000 $911
−90.89%
Since Feb 2025
$10,000 $1,548
−84.52%

If you had invested $10,000 in Sionna Therapeutics, Inc. (SION) at the close on February 7, 2025, the earliest close on record here, it would have been worth $1,548 at the close on October 21, 2026: −84.52% in total, −66.62% a year, over a partial period shorter than 10 years. A historical calculation from closing prices adjusted for splits and dividends, before fees and taxes.

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)−90.59%
2025 (partial year)+64.56%

As of October 21, 2026.

SION Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$0.00−$75.27M—
2024$0.00−$61.69M—
2023$0.00−$47.26M—
2022$0.00−$40.24M—
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$0.00—−$88.98M−$75.27M—
2024$0.00—−$70.56M−$61.69M—
2023$0.00—−$50.33M−$47.26M—
2022$0.00—−$41.37M−$40.24M—

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

Recent News

All 20 articles ↓

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

Sionna Therapeutics, Inc. (SION) is capitalised at $174.73M on the latest close. It is classified in the Biotechnology industry, within the Healthcare sector. Headcount on file is 59.

SION last closed at $3.87 on October 21, 2026. That is −$0.28 (−6.75%) against the previous close. Over the past 52 weeks the price has ranged from $3.78 to $54.97. The latest close sits 2.52% above that 52-week low.

Financial Health

Fiscal 2025 revenue came to $0.00. The same year closed with a net loss of $75.27M. Earnings per share on a trailing basis come to −2.16.

Across the 4 fiscal years on file, revenue moves from $0.00 in 2022 to $0.00 in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

No trailing P/E applies: the last reported earnings figure is negative.

Over the trailing twelve months the total return is −90.89%. The stored price history starts on February 7, 2025, and the total return since then is −84.52%. Daily returns over the trailing 1 year annualize to a volatility of 121.39%.

Growth & Income

No dividend is on file for SION.

So far in 2026 the total return is −90.59%.

Peer Comparison

Sionna Therapeutics, Inc. (SION) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Sionna Therapeutics, Inc. SION $174.73M —
Vertex Pharmaceuticals Incorporated VRTX $132.95B 30.4
Moderna, Inc. MRNA $98.14B —
Regeneron Pharmaceuticals, Inc. REGN $82.95B 19.9

The Biotechnology industry average P/E ratio is 16.6x. Sionna Therapeutics, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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About Sionna Therapeutics, Inc.

Sionna Therapeutics, Inc., a clinical-stage biopharmaceutical company, researches and develops medicines for the treatment of cystic fibrosis (CF). It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed cystic fibrosis transmembrane conductance regulator (CFTR) that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector that has completed Phase 1 trial; SION-2851, a TMD1-directed CFTR corrector that has completed Phase 1 trial; SION-451, which is nucleotide-binding domain 1 stabilizer in Phase 1 trial; and SION-719, which is nucleotide-binding domain 1 stabilizer in Phase 2a proof-of-concept trial. The company was formerly known as Sling Therapeutics, Inc. and changed its name to Sionna Therapeutics, Inc. in July 2021. Sionna Therapeutics, Inc. was incorporated in 2019 and is headquartered in Waltham, Massachusetts.

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