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NASDAQ · Biotechnology · USD

OnKure Therapeutics, Inc. (OKUR) Stock Analysis

OnKure Therapeutics, Inc. (OKUR) is a Biotechnology stock listed on NASDAQ and quoted in US Dollar.

Last Updated: October 21, 2026

OKUR

$2.30

−$0.06 (−2.54%)

Oct 21, 2026 · Market close

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Price History

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OKUR Key Statistics

As of Oct 21, 2026
Trading
Open
$2.37
Previous Close
$2.36
Day's Range
2.25–2.40
52-Week Range
2.01–5.38
Volume
232.76K
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
0.75
Valuation
Market Cap
$93.14M
P/E Ratio
unprofitable
EPS (ttm)Profit attributable to each share over the last twelve months.
−3.04
Financials (FY)
Revenue (FY)
$0.00
Net Income (FY)
−$59.52M
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
40.50M
1-Year Return
−23.33%
Dividend and dates
Avg Volume
247.20K

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

Key facts

As of October 21, 2026, OKUR closed at $2.30, −23.33% over 1 year.

OnKure Therapeutics, Inc. (OKUR) has a market capitalization of $93.14M.

In fiscal 2025, OKUR reported revenue of $0.00.

OKUR Stock Return by Calendar Year

OnKure Therapeutics, Inc. (OKUR) return since Apr 2021: what $10,000 became

1 year
$10,000 $7,667
−23.33%
5 years
$10,000 $328
−96.72%
Since Apr 2021
$10,000 $153
−98.47%

If you had invested $10,000 in OnKure Therapeutics, Inc. (OKUR) at the close on April 8, 2021, the earliest close on record here, it would have been worth $153 at the close on October 21, 2026: −98.47% in total, −52.98% a year, over a partial period shorter than 10 years. A historical calculation from closing prices adjusted for splits and dividends, before fees and taxes.

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)−20.69%
2025−66.28%
2024−46.25%
2023−31.33%
2022−72.75%
2021 (partial year)−43.00%

As of October 21, 2026.

OKUR Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$0.00−$59.52M—
2024$0.00−$52.67M—
2023$0.00−$35.31M—
2022$0.00−$29.51M—
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$0.00—−$62.95M−$59.52M—
2024$0.00—−$54.39M−$52.67M—
2023$0.00—−$36.93M−$35.31M—
2022$0.00—−$29.77M−$29.51M—

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

Recent News

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

OnKure Therapeutics, Inc. (OKUR) carries a market capitalisation of $93.14M. The company sits in the Healthcare sector, in the Biotechnology industry. Headcount on file is 45.

OKUR last closed at $2.30 on October 21, 2026. That is −$0.06 (−2.54%) against the previous close. Over the past 52 weeks the price has ranged from $2.01 to $5.38. The latest close sits 14.43% above that 52-week low.

Financial Health

Fiscal 2025 revenue came to $0.00. The same year closed with a net loss of $59.52M. Earnings per share on a trailing basis come to −3.04.

Across the 4 fiscal years on file, revenue moves from $0.00 in 2022 to $0.00 in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

No trailing P/E applies: the last reported earnings figure is negative.

Beta against the wider market is reported at 0.75. Daily returns over the trailing 5 years annualize to a volatility of 84.97%. The trailing one-year total return is −23.33%. Measured over 5 years, that is −49.51% a year compounded.

Growth & Income

No dividend is on file for OKUR.

2026 is still running; the total return is −20.69% year to date. The strongest complete calendar year on file is 2023 at −31.33%; the weakest is 2022 at −72.75%. Of the 4 complete calendar years on file, 0 finished higher.

Peer Comparison

OnKure Therapeutics, Inc. (OKUR) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
OnKure Therapeutics, Inc. OKUR $93.14M —
Vertex Pharmaceuticals Incorporated VRTX $132.95B 30.4
Moderna, Inc. MRNA $98.14B —
Regeneron Pharmaceuticals, Inc. REGN $82.95B 19.9

The Biotechnology industry average P/E ratio is 16.6x. OnKure Therapeutics, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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About OnKure Therapeutics, Inc.

OnKure Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of precision medicines that target biologically validated drivers of cancers and other diseases. Its lead product candidate includes OKI-219, a selective inhibitor of phosphoinositide 3-kinase alpha (PI3Ka) harboring the H1047R mutation that is in Phase 1 clinical trial for the treatment of solid tumors, including breast cancer. The company was founded in 2011 and is headquartered in Boulder, Colorado.

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