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Insmed Incorporated (INSM) Stock Analysis

Healthcare

Insmed Incorporated

$108.87

+$2.63 (+2.48%)

Last Updated: May 26, 2026

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Analysis

Company Overview

Insmed Incorporated operates within the healthcare sector, specifically functioning as a biotechnology company dedicated to developing and commercializing therapies for patients suffering from serious and rare diseases across the United States, Europe, Japan, and internationally. The firm's primary commercial focus includes offering ARIKAYCE for the treatment of refractory nontuberculous mycobacterial lung infections, while simultaneously advancing a pipeline through phase 3 clinical trials. As of the latest reporting period, the company holds a substantial market capitalization of $31.04 billion and generates annual revenue of $606.42 million, employing a workforce of 1,664 individuals. These valuation and revenue figures indicate that Insmed is a significant market entity within the biotechnology space, commanding a price-to-sales multiple of 51.18 that reflects high market expectations for its proprietary drug portfolio and future clinical developments.

Financial Health

The company reports a trailing twelve-month revenue of $606.42 million, yet this revenue supports a net income loss of -$1,276,775,040, revealing a cost structure where expenses significantly outweigh top-line earnings. Additionally, the EBITDA stands at -$980,464,000, which further highlights the aggressive investment in research and development or commercialization efforts required to sustain the current business model. Free cash flow for the period is -$534,054,880, indicating that the company is currently burning cash rather than generating liquidity, which limits its immediate financial flexibility to fund operations without external capital. Despite these negative income metrics, Insmed maintains a robust cash position of $1.43 billion against total debt of $749.54 million, resulting in a debt-to-equity ratio of 101.43 that suggests a highly leveraged balance sheet relative to its equity base. The gross margin is reported at 79.7%, demonstrating high efficiency in production costs, whereas the operating margin sits at -94.6% and the profit margin at -210.5%, illustrating the severe drag of operating expenses and net losses on profitability. Liquidity is supported by a current ratio of 3.83, which indicates a strong ability to meet short-term obligations with current assets. Return on Equity is -249.3% and return on assets is -29.0%, metrics that reveal management is currently generating negative returns on the capital invested in the company's assets and equity structure.

Valuation Assessment

The trailing twelve-month P/E ratio is N/A due to the net losses, while the forward P/E is listed at 359.96, implying that the market is pricing in significant future earnings recovery or growth to justify the current stock valuation. The price-to-book ratio stands at 41.75, indicating that the market values Insmed at a massive premium over its book value, likely reflecting confidence in the potential of its clinical pipeline and ARIKAYCE sales. Alternative valuation metrics such as the price-to-sales ratio of 51.18 and an EV/EBITDA of -30.96 suggest that traditional multiple-based analysis is less applicable, as the negative earnings drive the EV/EBITDA into negative territory. The stock has demonstrated significant volatility, trading between a 52-week high of $212.75 and a 52-week low of $60.40. Based on the low of $60.40, the current price sits at a level that suggests the stock has recovered from its annual trough but remains below its 52-week peak. The beta value is 1.17, which indicates that the stock is more volatile than the broader market, experiencing price swings that are approximately 17% greater than the market average during periods of fluctuation.

Growth & Income

Revenue growth year-over-year is 152.6%, showing a dramatic expansion in sales, whereas earnings growth is N/A due to the company's ongoing losses, implying that top-line expansion is not yet translating into profitability. The company does not pay dividends, evidenced by a dividend yield of N/A and a payout ratio of 0.0%, which means the firm retains all its earnings to reinvest into its research and development activities rather than returning capital to shareholders. Consequently, the overall growth and income profile is characterized by aggressive revenue scaling supported by a strong cash balance but constrained by substantial operating losses that prevent any current income generation for investors.

Peer Comparison

Insmed Incorporated (INSM) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Insmed Incorporated INSM $23.60B N/A
Vertex Pharmaceuticals Incorporated VRTX $110.64B 25.8
Regeneron Pharmaceuticals, Inc. REGN $66.98B 15.6
argenx SE ARGX $50.52B 36.0

The Biotechnology industry average P/E ratio is 53.8x. Insmed Incorporated trades at a P/E of N/A.

This analysis is AI-generated for informational purposes only and should not be considered financial advice. Data may be delayed or inaccurate. Always do your own research and consult a qualified financial advisor before making investment decisions.

About Insmed Incorporated

Insmed Incorporated develops and commercializes therapies for patients with serious and rare diseases in the United States, Europe, Japan, and internationally. The company offers ARIKAYCE for the treatment of refractory nontuberculous mycobacterial lung infections, as well as is in phase 3 clinical trial for the treatment of mycobacterium avium complex lung disease as part of a combination antibacterial drug regimen for adult patients. It also develops brensocatib, an oral reversible inhibitor of dipeptidyl peptidase 1(DPP1) that is in phase 3 clinical trial for the treatment of bronchiectasis; and in phase 2 clinical trial for the treatment of chronic rhinosinusitis without nasal polyps and hidradenitis suppurativa. In addition, the company is developing treprostinil palmitil inhalation powder, an inhaled formulation of a treprostinil prodrug treprostinil palmitil, which is in phase 3 clinical trial for the treatment of pulmonary hypertension associated with interstitial lung disease; and phase 2 clinical trial for the treatment of pulmonary arterial hypertension. Further, it develops INS1201, a microdystrophin adeno-associated virus gene replacement therapy which is in phase 1 clinical trial for the treatment of Duchenne muscular dystrophy, as well as it is also developing pre-clinical research programs for gene therapy, AI-driven protein engineering, protein manufacturing, RNA end-joining, and synthetic rescue. In addition, it provides INS1148, monoclonal antibody targeting stem cell factor called SCF248 that is in phase-2 clinical trial for the treatment of interstitial lung disease, and asthma; and INS1202, an intrathecally delivered gene therapy which is in phase 1 of clinical trial for the treatment of amyotrophic lateral sclerosis. The company was founded in 1988 and is headquartered in Bridgewater, New Jersey.

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Key Statistics

Market Cap
$23.60B
P/E Ratio
N/A
52-Week High
$212.75
52-Week Low
$65.56
Avg Volume
2.85M
Beta
0.89

Data provided by Yahoo Finance via yfinance. Updated daily.

Company Info

Exchange
NASDAQ
Country
United States
Employees
1,664