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NASDAQ · Biotechnology · USD

Aptevo Therapeutics Inc. (APVO) Stock Analysis

Aptevo Therapeutics Inc. (APVO) is a Biotechnology stock listed on NASDAQ and quoted in US Dollar.

APVO

$1.74

+$0.03 (+1.75%)

Sep 4, 2026 · Market close

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Price History

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APVO Key Statistics

As of Sep 4, 2026
Trading
Open
$1.74
Previous Close
$1.71
Day's Range
1.64–1.80
52-Week Range
1.37–48.78
Volume
272.10K
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
1.61
Valuation
Market Cap
$3.15M
P/E Ratio
0.00
EPS (ttm)Profit attributable to each share over the last twelve months.
467.36
Financials (FY)
Revenue (FY)
$0.00
Net Income (FY)
−$25.97M
Profit marginThe share of revenue left as profit after all costs and taxes.
0.00%
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
1.81M
1-Year Return
−94.07%
Dividend and dates
Avg Volume
96.85K

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

APVO Stock Return by Calendar Year

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)−81.55%
2025−99.39%
2024−98.54%
2023−92.20%
2022−70.52%
2021−78.53%
2020+299.67%
2019−48.43%
2018−70.05%
2017+73.77%
2016 (partial year)−10.95%

As of September 4, 2026.

APVO Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$0.00−$25.97M
2024$0.00−$24.13M
2023$0.00−$17.41M
2022$3.11M$8.03M257.8%
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$0.00−$26.31M−$25.97M
2024$0.00−$24.60M−$24.13M
2023$0.00−$28.88M−$17.41M
2022$3.11M−$28.64M$8.03M257.8%

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

APVO Valuation vs Biotechnology Median

Median of 656 stocks
MetricAPVOBiotechnology medianvs median
P/E0.0012.570.0x the median
Profit margin0.00%0.00%0.0 pts above

Medians across 656 Biotechnology stocks that report the metric. Medians, not averages, so one outlier cannot move them. As of September 4, 2026.

Recent News

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

The market values Aptevo Therapeutics Inc. (APVO) at $3.15M. It is classified in the Biotechnology industry, within the Healthcare sector. Headcount on file is 33.

The 52-week range on file runs from $1.37 to $48.78. The most recent close on file for APVO is $1.74, dated September 4, 2026. That is +$0.03 (+1.75%) against the previous close. The latest close sits 27.01% above that 52-week low.

Financial Health

The most recent full year on file, fiscal 2025, shows revenue of $0.00. The same year closed with a net loss of $25.97M. Profit margin runs at 0%. Trailing earnings per share are 467.36.

Across the 4 fiscal years on file, revenue moves from $3.11M in 2022 to $0.00 in 2025. Of those 4 years, 1 report positive net income.

Valuation Assessment

APVO trades at a trailing price-to-earnings ratio of 0.

Over the trailing twelve months the price has returned −94.07%. Measured over 10 years, that is −80.49% a year compounded. The reported beta is 1.61. Daily returns over the trailing 10 years annualize to a volatility of 127.65%.

Growth & Income

The record shows no dividend for APVO.

Across the complete calendar years on file, 2020 returned +299.67% and 2025 returned −99.39%. Of the 9 complete calendar years on file, 2 finished higher. So far in 2026 the price is −81.55%.

Peer Comparison

Aptevo Therapeutics Inc. (APVO) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Aptevo Therapeutics Inc. APVO $3.15M 0.0
Vertex Pharmaceuticals Incorporated VRTX $138.42B 32.5
Regeneron Pharmaceuticals, Inc. REGN $85.22B 20.5
argenx SE ARGX $64.25B 40.1

The Biotechnology industry average P/E ratio is 12.6x. Aptevo Therapeutics Inc. trades at a P/E of 0.0.

Every figure above is read from this page's own data on each nightly rebuild. Informational only, not financial advice. As of September 4, 2026.

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About Aptevo Therapeutics Inc.

Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. The company develops its products using ADAPTIR and ADAPTIR-FLEX platforms to generate monospecific, bispecific, and multi-specific antibody candidates capable of enhancing the human immune system against cancer cells. Its lead clinical blood cancer candidate is mipletamig that is in Phase 1b/2 clinical trial for the treatment of acute myelogenous leukemia. The company also develops ALG.APV-527, a novel investigational bispecific ADAPTIR candidate that is in Phase 1 clinical trial for the treatment malignant pleural mesothelioma, non-small cell lung, gastric/gastro-esophageal, head and neck squamous cell carcinoma, pancreatic, renal, ovarian, prostate, breast, cervical, colorectal, endometrial, and bladder cancers; APVO603, a preclinical dual agonist bispecific ADAPTIR candidate to treat multiple solid tumors; APVO442, a preclinical bispecific candidate based on the ADAPTIR-FLEX platform technology for the treatment of multiple solid tumors; and APVO711, a preclinical dual mechanism bispecific ADAPTIR candidate to treat prostate cancer. It has a collaboration and option agreement with Alligator Bioscience AB to develop ALG.APV-527. Aptevo Therapeutics Inc. was incorporated in 2016 and is headquartered in Seattle, Washington.

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