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NASDAQ · Biotechnology · USD

Aptevo Therapeutics Inc. (APVO) Stock Analysis

Aptevo Therapeutics Inc. (APVO) is a Biotechnology stock listed on NASDAQ and quoted in US Dollar.

Last Updated: October 21, 2026

APVO

$1.60

−$0.01 (−0.93%)

Oct 21, 2026 · Market close

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Price History

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APVO Key Statistics

As of Oct 21, 2026
Trading
Open
$1.62
Previous Close
$1.62
Day's Range
1.60–1.65
52-Week Range
1.37–28.44
Volume
7.94K
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
1.68
Valuation
Market Cap
$2.90M
Financials (FY)
Revenue (FY)
$0.00
Net Income (FY)
−$25.97M
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
1.81M
1-Year Return
−94.34%
Dividend and dates
Avg Volume
93.06K

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

Key facts

As of October 21, 2026, APVO closed at $1.60, −94.34% over 1 year.

Aptevo Therapeutics Inc. (APVO) has a market capitalization of $2.90M.

In fiscal 2025, APVO reported revenue of $0.00.

APVO Stock Return by Calendar Year

Aptevo Therapeutics Inc. (APVO) 10-year return: what $10,000 became

1 year
$10,000 $566
−94.34%
5 years
$10,000 $0.002
−99.99998%
10 years
$10,000 $0.001
−99.99999%

If you had invested $10,000 in Aptevo Therapeutics Inc. (APVO) 10 years ago, at the close on October 21, 2016, it would have been worth $0.001 at the close on October 21, 2026: −99.99999% in total, −80.37% a year. A historical calculation from closing prices adjusted for splits and dividends, before fees and taxes.

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)−83.03%
2025−99.39%
2024−98.54%
2023−92.20%
2022−70.52%
2021−78.53%
2020+299.67%
2019−48.43%
2018−70.05%
2017+73.77%
2016 (partial year)−10.95%

As of October 21, 2026.

APVO Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$0.00−$25.97M—
2024$0.00−$24.13M—
2023$0.00−$17.41M—
2022$3.11M$8.03M257.8%
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$0.00—−$26.31M−$25.97M—
2024$0.00—−$24.60M−$24.13M—
2023$0.00—−$28.88M−$17.41M—
2022$3.11M—−$28.64M$8.03M257.8%

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

Recent News

All 13 articles ↓

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

The market values Aptevo Therapeutics Inc. (APVO) at $2.90M. It is classified in the Biotechnology industry, within the Healthcare sector. Headcount on file is 33.

The 52-week range on file runs from $1.37 to $28.44. The most recent close on file for APVO is $1.60, dated October 21, 2026. That is −$0.01 (−0.93%) against the previous close. The latest close sits 16.79% above that 52-week low.

Financial Health

The most recent full year on file, fiscal 2025, shows revenue of $0.00. The same year closed with a net loss of $25.97M.

Across the 4 fiscal years on file, revenue moves from $3.11M in 2022 to $0.00 in 2025. Of those 4 years, 1 report positive net income.

Valuation Assessment

Over the trailing twelve months the total return is −94.34%. Measured over 10 years, that is −80.37% a year compounded. The reported beta is 1.68. Daily returns over the trailing 10 years annualize to a volatility of 127.52%.

Growth & Income

The record shows no dividend for APVO.

Across the complete calendar years on file, 2020 returned +299.67% and 2025 returned −99.39%. Of the 9 complete calendar years on file, 2 finished higher. So far in 2026 the total return is −83.03%.

Peer Comparison

Aptevo Therapeutics Inc. (APVO) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Aptevo Therapeutics Inc. APVO $2.90M —
Vertex Pharmaceuticals Incorporated VRTX $132.95B 30.4
Moderna, Inc. MRNA $98.14B —
Regeneron Pharmaceuticals, Inc. REGN $82.95B 19.9

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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About Aptevo Therapeutics Inc.

Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. The company develops its products using ADAPTIR and ADAPTIR-FLEX platforms to generate monospecific, bispecific, and multi-specific antibody candidates capable of enhancing the human immune system against cancer cells. Its lead clinical blood cancer candidate is mipletamig that is in Phase 1b/2 clinical trial for the treatment of acute myelogenous leukemia. The company also develops ALG.APV-527, a novel investigational bispecific ADAPTIR candidate that is in Phase 1 clinical trial for the treatment malignant pleural mesothelioma, non-small cell lung, gastric/gastro-esophageal, head and neck squamous cell carcinoma, pancreatic, renal, ovarian, prostate, breast, cervical, colorectal, endometrial, and bladder cancers; APVO603, a preclinical dual agonist bispecific ADAPTIR candidate to treat multiple solid tumors; APVO442, a preclinical bispecific candidate based on the ADAPTIR-FLEX platform technology for the treatment of multiple solid tumors; and APVO711, a preclinical dual mechanism bispecific ADAPTIR candidate to treat prostate cancer. It has a collaboration and option agreement with Alligator Bioscience AB to develop ALG.APV-527. Aptevo Therapeutics Inc. was incorporated in 2016 and is headquartered in Seattle, Washington.

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