StockVS

NYSE · Biotechnology · USD

Annovis Bio, Inc. (ANVS) Stock Analysis

Annovis Bio, Inc. (ANVS) is a Biotechnology stock listed on NYSE and quoted in US Dollar.

Last Updated: October 21, 2026

ANVS

$0.99

+$0.01 (+1.52%)

Oct 21, 2026 · Market close

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Price History

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ANVS Key Statistics

As of Oct 21, 2026
Trading
Open
$1.00
Previous Close
$0.98
Day's Range
0.99–1.04
52-Week Range
0.95–5.50
Volume
546.33K
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
1.23
Valuation
Market Cap
$42.39M
P/E Ratio
unprofitable
EPS (ttm)Profit attributable to each share over the last twelve months.
−1.75
Financials (FY)
Revenue (FY)
$0.00
Net Income (FY)
−$28.85M
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
42.68M
1-Year Return
−54.23%
Dividend and dates
Avg Volume
868.55K

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

Key facts

As of October 21, 2026, ANVS closed at $0.99, −54.23% over 1 year.

Annovis Bio, Inc. (ANVS) has a market capitalization of $42.39M.

In fiscal 2025, ANVS reported revenue of $0.00.

ANVS Stock Return by Calendar Year

Annovis Bio, Inc. (ANVS) return since Jan 2020: what $10,000 became

1 year
$10,000 $4,577
−54.23%
5 years
$10,000 $338
−96.62%
Since Jan 2020
$10,000 $1,036
−89.64%

If you had invested $10,000 in Annovis Bio, Inc. (ANVS) at the close on January 29, 2020, the earliest close on record here, it would have been worth $1,036 at the close on October 21, 2026: −89.64% in total, −28.62% a year, over a partial period shorter than 10 years. A historical calculation from closing prices adjusted for splits and dividends, before fees and taxes.

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)−71.29%
2025−31.21%
2024−73.10%
2023+39.24%
2022−23.61%
2021+133.16%
2020−21.38%

As of October 21, 2026.

ANVS Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$0.00−$28.85M—
2024$0.00−$24.59M—
2023$0.00−$56.20M—
2022$0.00−$25.33M—
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$0.00—−$29.70M−$28.85M—
2024$0.00—−$26.69M−$24.59M—
2023$0.00—−$45.04M−$56.20M—
2022$0.00—−$25.51M−$25.33M—

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

Recent News

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

Annovis Bio, Inc. (ANVS) carries a market capitalisation of $42.39M. The company sits in the Healthcare sector, in the Biotechnology industry. Headcount on file is 7.

The 52-week range on file runs from $0.95 to $5.50. The most recent close on file for ANVS is $0.99, dated October 21, 2026. That is +$0.01 (+1.52%) against the previous close. The latest close sits 4.55% above that 52-week low.

Financial Health

In fiscal 2025, Annovis Bio, Inc. reported revenue of $0.00. The same year closed with a net loss of $28.85M. Trailing earnings per share are −1.75.

Across the 4 fiscal years on file, revenue moves from $0.00 in 2022 to $0.00 in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

The record shows negative trailing earnings, so no price-to-earnings ratio is published.

Beta against the wider market is reported at 1.23. Annualized volatility over the trailing 6 years is 125.68%. Over the trailing twelve months the total return is −54.23%. Across 5 years the annualized return works out at −49.21%.

Growth & Income

The record shows no dividend for ANVS.

The strongest complete calendar year on file is 2021 at +133.16%; the weakest is 2024 at −73.10%. Of the 6 complete calendar years on file, 2 finished higher. So far in 2026 the total return is −71.29%.

Peer Comparison

Annovis Bio, Inc. (ANVS) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Annovis Bio, Inc. ANVS $42.39M —
Vertex Pharmaceuticals Incorporated VRTX $132.95B 30.4
Moderna, Inc. MRNA $98.14B —
Regeneron Pharmaceuticals, Inc. REGN $82.95B 19.9

The Biotechnology industry average P/E ratio is 16.6x. Annovis Bio, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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About Annovis Bio, Inc.

Annovis Bio, Inc., a clinical stage drug platform company, develops drugs to treat neurodegeneration in the United States. The company's lead product candidate is Buntanetap, which is in phase 3 to treat alzheimer's disease, as well as in open-label phase 3 to treat parkinson's disease. It also develops ANVS405, which is in phase 2 and 3 clinical trials for the treatment of traumatic brain injury and/or stroke; and ANVS301, which finished phase 1 clinical trial developed to increase cognitive capability in later stages of alzheimer's disease and dementia. Annovis Bio, Inc. was incorporated in 2008 and is headquartered in Malvern, Pennsylvania.

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