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TSX · CAD · ETF

iShares Genomics Immunology and Healthcare Index ETF CAD (XDNA.TO) ETF Analysis

XDNA.TO
Expense ratio 0.44% Yield 0.19% Assets CA$18.73M Since April 26, 2022 Family BlackRock Asset Management Canada Ltd

Last Updated: October 21, 2026

CA$61.95
+CA$0.12 (+0.19%)

October 21, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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XDNA.TO Annualized Returns

PeriodAnnualizedCA$100 becomes
1 year+70.48%CA$170.48
3 years+35.30%CA$247.70
Since May 4, 2022+10.28%CA$154.82

Returns are total returns computed from daily closes, with dividends reinvested. As of October 21, 2026.

XDNA.TO Return by Calendar Year

2022 and 2026 are partial years

View as table ↓View as chart ↑
YearReturn
2026 (partial year)+66.76%
2025+12.10%
2024+5.54%
2023−7.84%
2022 (partial year)−14.85%

XDNA.TO Monthly Returns

−11%+19%
YearJanFebMarAprMayJunJulAugSepOctNovDec
2026+8.2+8.4−8.5+3.3+3.4+16.9−4.3+18.0+11.5−1.2——
2025+2.5−1.7−8.0−4.3−2.2+0.8+7.2+1.4+7.5+7.7+8.7−6.1
2024−2.2+8.5−0.1−4.5+3.5−1.2+8.5−2.7−1.4+1.7+2.0−5.5
2023+6.1−9.1−3.5+0.7+2.2−4.6+2.2−2.8−10.2−7.5+9.6+11.6
2022—————+0.8+10.1−6.2−4.5+0.3−0.5−8.7

Monthly total returns with dividends reinvested; each cell prints its signed value.

XDNA.TO Volatility & Risk

Volatility: 4 yrs · Beta: 3 yrs
Annualized volatility
24.92%
Beta (3y)
1.37
Best year
+12.10%

2025

Worst year
−7.84%

2023

Volatility is the annualized standard deviation of daily returns. As of October 21, 2026.

Top Holdings

# Symbol Name Weight
1 MRNA Moderna Inc 11.21%
2 TWST Twist Bioscience Corp 7.71%
3 IOVA Iovance Biotherapeutics Inc 4.98%
4 GMAB.CO Genmab AS 3.99%
5 RVMD Revolution Medicines Inc Ordinary Shares 3.8%
6 BAYN.DE Bayer AG 3.6%
7 MRK Merck & Co Inc 3.32%
8 4502.T Takeda Pharmaceutical Co Ltd 3.32%
9 REGN Regeneron Pharmaceuticals Inc 3.29%
10 INCY Incyte Corp 3.27%

Analysis

Data-derived

Fund Overview

iShares Genomics Immunology and Healthcare Index ETF CAD (XDNA.TO) is an exchange-traded fund. The fund holds CA$18.73M in total net assets. Annual costs run at an expense ratio of 0.44%. On a CA$10,000 position that is CA$44.00 a year. The fund is issued by BlackRock Asset Management Canada Ltd. It has been trading since April 26, 2022.

The largest positions on file are Moderna Inc (MRNA), Twist Bioscience Corp (TWST), and Iovance Biotherapeutics Inc (IOVA). Moderna Inc alone accounts for 11.21% of the portfolio. The ten largest positions together make up 48.49% of the fund.

Performance Analysis

XDNA.TO last closed at CA$61.95 on October 21, 2026. The trailing one-year total return is +70.48%. Measured over 3 years, that is +35.30% a year compounded. The fund distributes at a trailing yield of 0.19%.

The strongest complete calendar year on file is 2025 at +12.10%; the weakest is 2023 at −7.84%. Of the 3 complete calendar years on file, 2 finished higher. 2026 is still running; the total return is +66.76% year to date.

Price & Risk Profile

The 52-week range on file runs from CA$35.45 to CA$63.12. The latest close sits 74.75% above that 52-week low. Daily returns over the trailing 4 years annualize to a volatility of 24.92%. The reported beta is 1.37. The volatility figure is calculated from the stored daily closes, the same series the charts on this page use.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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