OTC Markets · Biotechnology · USD

Synlogic, Inc. (SYBX) Stock Analysis

Synlogic, Inc. (SYBX) is a Biotechnology stock listed on OTC Markets and quoted in US Dollar.

SYBX

$1.17

−$0.05 (−4.10%)

Sep 4, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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SYBX Key Statistics

As of Sep 4, 2026

Trading

Open: $1.20
Previous Close: $1.22
Day's Range: 1.17–1.20
52-Week Range: 0.54–1.87
Volume: 500

Valuation

Market Cap: $14.33M
P/E Ratio: unprofitable
EPS (ttm): −0.05

Financials (FY)

Revenue (FY): $0.00−100.00%
Net Income (FY): −$1.01M
Profit margin: 0.00%
Shares Outstanding: 12.25M
1-Year Return: −19.86%

Dividend and dates

Avg Volume: 72.42K

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

SYBX Stock Return by Calendar Year

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

+12.04%−68.60%+4.46%

2016*2017201820192020202120222023202420252026*

Year	Return
2026 (partial year)	+4.46%
2025	−20.00%
2024	−63.64%
2023	−66.23%
2022	−68.60%
2021	+12.04%
2020	−16.28%
2019	−63.20%
2018	−27.73%
2017	−23.02%
2016 (partial year)	−57.66%

As of September 4, 2026.

SYBX Revenue and Earnings by Fiscal Year

FY ends December

RevenueNet income

2022202320242025

Fiscal year	Revenue	Net income	Net margin
2025	$0.00	−$1.01M	—
2024	$8.00K	−$23.36M	−291987.5%
2023	$3.37M	−$61.27M	−1817.7%
2022	$1.18M	−$66.15M	−5605.7%

Fiscal year	Revenue	Gross profit	Operating income	Net income	Net margin
2025	$0.00	—	−$3.53M	−$1.01M	—
2024	$8.00K	—	−$15.78M	−$23.36M	−291987.5%
2023	$3.37M	—	−$55.16M	−$61.27M	−1817.7%
2022	$1.18M	—	−$67.42M	−$66.15M	−5605.7%

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

SYBX Valuation vs Biotechnology Median

Median of 656 stocks

Metric	SYBX	Biotechnology median	vs median
Profit margin	0.00%	0.00%	0.0 pts above

Medians across 656 Biotechnology stocks that report the metric. Medians, not averages, so one outlier cannot move them. As of September 4, 2026.

Analysis

Data-derived

Company Overview

Synlogic, Inc. (SYBX) carries a market capitalisation of $14.33M. It is classified in the Biotechnology industry, within the Healthcare sector. Headcount on file is 1.

The 52-week range on file runs from $0.54 to $1.87. SYBX last closed at $1.17 on September 4, 2026. That is −$0.05 (−4.10%) against the previous close. The latest close sits 116.67% above that 52-week low.

Financial Health

In fiscal 2025, Synlogic, Inc. reported revenue of $0.00. That is −100.00% against the prior fiscal year, when revenue was $8.00K. The same year closed with a net loss of $1.01M. The reported profit margin is 0%. Earnings per share on a trailing basis come to −0.05.

Across the 4 fiscal years on file, revenue moves from $1.18M in 2022 to $0.00 in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

The record shows negative trailing earnings, so no price-to-earnings ratio is published.

Annualized volatility over the trailing 10 years is 84.56%. Over the trailing twelve months the price has returned −19.86%. Measured over 10 years, that is −41.76% a year compounded.

Growth & Income

The record shows no dividend for SYBX.

So far in 2026 the price is +4.46%. The strongest complete calendar year on file is 2021 at +12.04%; the weakest is 2022 at −68.60%. Of the 9 complete calendar years on file, 1 finished higher.

Peer Comparison

Synlogic, Inc. (SYBX) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company	Ticker	Market Cap	P/E Ratio
Synlogic, Inc.	SYBX	$14.33M	—
Vertex Pharmaceuticals Incorporated	VRTX	$138.42B	32.5
Regeneron Pharmaceuticals, Inc.	REGN	$85.22B	20.5
argenx SE	ARGX	$64.25B	40.1

The Biotechnology industry average P/E ratio is 12.6x. Synlogic, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each nightly rebuild. Informational only, not financial advice. As of September 4, 2026.

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About Synlogic, Inc.

Synlogic, Inc. does not have significant operations. It was previously engaged in the discovery and development of synthetic biotics to treat metabolic diseases. Synlogic, Inc. is based in Winchester, Massachusetts.

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