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Guardant Health, Inc. (GH) Stock Analysis

Healthcare

Guardant Health, Inc.

$119.85

+$0.90 (+0.76%)

Last Updated: May 26, 2026

Price History

Analysis

Company Overview

Guardant Health, Inc. operates as a precision oncology company that provides blood and tissue tests, along with comprehensive data sets, to support diagnostic and research efforts both in the United States and internationally. The company's core offerings include the Guardant360 CDx test, which functions as a liquid biopsy for tumor mutation profiling, and the Guardant360 Liquid test, which measures over 740 genes to support clinical applications. This entity functions within the broader Healthcare sector, specifically focusing on the Diagnostics & Research industry, positioning it as a specialized player in medical technology and genomic analysis. The company demonstrates significant scale with a market capitalization of $11.68B and annual revenue of $982.02M, supported by an employee base of 2490 individuals. These financial figures indicate that Guardant Health commands a substantial valuation relative to its current sales volume, reflecting investor confidence in its technological capabilities despite the company currently operating at a loss.

Financial Health

The company reported a trailing twelve-month revenue of $982.02M, while simultaneously posting a net income loss of $-416,276,992 and an EBITDA of $-396,561,984. The substantial gap between the positive revenue figure and the significant negative net income reveals a heavy cost structure where operating expenses, likely driven by research and development and commercialization costs, far exceed gross profits. Free cash flow stands at $-88,105,872, indicating that the company is currently burning cash, which limits its immediate financial flexibility and reliance on external capital markets or internal cash reserves to fund operations. When analyzing profitability metrics, the gross margin sits at 64.5%, suggesting that the company retains a healthy portion of revenue after direct costs, yet this is insufficient to cover overheads. The operating margin is negative at -42.9%, and the profit margin is similarly depressed at -42.4%, indicating that the business model is currently unsustainable without significant cost reductions or revenue expansion. On the balance sheet, the company holds $1.20B in cash against $1.71B in debt, creating a net debt position, and the debt-to-equity ratio is listed as N/A due to the negative equity position. Despite the leverage, the current ratio of 4.84 indicates a robust short-term liquidity position, suggesting the company has ample current assets to cover its short-term liabilities. Return on Equity is N/A given the negative shareholders' equity, and the return on assets stands at -15.6%, revealing that management is currently utilizing the asset base to generate negative returns rather than positive earnings.

Valuation Assessment

The trailing P/E ratio is N/A due to negative earnings, while the forward P/E is reported at -143.64, a metric that implies the market is pricing in significant future earnings recovery or is currently discounting the stock heavily based on negative current performance. The price-to-book ratio is -117.21, which indicates a market valuation that is negative relative to book value, reflecting the intangible nature of the business and the current accounting losses rather than a traditional market premium over tangible assets. Alternative valuation metrics such as the price-to-sales ratio of 11.90 and the EV/EBITDA of -30.75 suggest that investors are valuing the company primarily on its revenue growth potential and intellectual property rather than current profitability. The stock has traded between a 52-week high of $120.74 and a 52-week low of $36.36, and without the specific current price, the valuation is assessed against this wide trading range which highlights the stock's high volatility. The beta value of 1.69 indicates that the stock price is significantly more volatile than the broader market, moving with greater amplitude in response to sector-specific news or general market shifts.

Growth & Income

Revenue growth stands at 39.4% year-over-year, demonstrating strong top-line expansion, whereas earnings growth is N/A because the company remains unprofitable, implying that revenue increases are currently being consumed by operational costs rather than translating into bottom-line gains. The company does not pay a dividend, evidenced by a dividend yield of N/A and a payout ratio of 0.0%, which means the company reinvests all available capital and generated cash flow back into the business to fund its research and development activities rather than returning cash to shareholders. This growth-at-all-costs strategy is typical for biotechnology firms in the early stages of commercialization where profitability is expected to arrive later in the product lifecycle. The overall growth and income profile is characterized by rapid revenue acceleration with no current income generation, relying entirely on market confidence in future profitability to sustain the current valuation.

Peer Comparison

Guardant Health, Inc. (GH) operates in the Diagnostics & Research industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Guardant Health, Inc. GH $15.89B N/A
Thermo Fisher Scientific Inc. TMO $166.55B 24.6
Danaher Corporation DHR $122.31B 33.4
IDEXX Laboratories, Inc. IDXX $43.95B 41.0

The Diagnostics & Research industry average P/E ratio is 32.5x. Guardant Health, Inc. trades at a P/E of N/A.

This analysis is AI-generated for informational purposes only and should not be considered financial advice. Data may be delayed or inaccurate. Always do your own research and consult a qualified financial advisor before making investment decisions.

About Guardant Health, Inc.

Guardant Health, Inc., a precision oncology company, provides blood and tissue tests, and data sets in the United States and internationally. The company offers Guardant360 CDx test, a liquid biopsy test for tumor mutation profiling; Guardant360 Liquid test, which measures 740+ genes and supports all guideline-recommended biomarkers; Guardant Reveal test, a blood test that utilizes circulating tumor DNA to detect cancer at the molecular level; and Guardant360 Tissue test, a molecular profiling test for tumor tissue that provides genomic, transcriptomic, and epigenomic insights. It also provides Shield blood test for colorectal cancer screening in adults. In addition, the company offers GuardantINFINITY test that provides insights into the complexities of tumor molecular profiles and immune response to advance cancer research and therapy development; GuardantOMNI test covers 500 genes, including genes associated with homologous recombination repair deficiency and biomarkers for immuno-oncology applications; GuardantINFORM, which provides longitudinal biological insight into tumor evolution alongside longitudinal clinical outcomes; and GuardantConnect, an integrated software-based solution designed for clinical and biopharmaceutical customers to connect patients tested with assays with actionable alterations with potentially relevant clinical studies. Further, it provides Smart Platform, which delivers multiomic insights leveraging genomic, epigenomic, and RNA-based data that are scalable from research to the clinic. Additionally, the company offers development services, including companion diagnostic development and regulatory approval, clinical study setup, monitoring and maintenance, testing development and support, technologies licensing, and kit fulfillment and delivery of Shield screening tests. It has a strategic collaboration with Nuvalent, Inc. for oncology drug development. The company was incorporated in 2011 and is headquartered in Palo Alto, California.

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Key Statistics

Market Cap
$15.89B
P/E Ratio
N/A
52-Week High
$121.01
52-Week Low
$37.73
Avg Volume
2.07M
Beta
1.49

Data provided by Yahoo Finance via yfinance. Updated daily.

Company Info

Exchange
NASDAQ
Country
United States
Employees
2,490