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NASDAQ · Biotechnology · USD

Zentalis Pharmaceuticals, Inc. (ZNTL) Stock Analysis

Zentalis Pharmaceuticals, Inc. (ZNTL) is a Biotechnology stock listed on NASDAQ and quoted in US Dollar.

ZNTL

$3.99

−$0.12 (−2.92%)

Sep 4, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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ZNTL Key Statistics

As of Sep 4, 2026
Trading
Open
$4.05
Previous Close
$4.11
Day's Range
3.92–4.19
52-Week Range
1.21–6.95
Volume
997.80K
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
1.86
Valuation
Market Cap
$377.74M
P/E Ratio
unprofitable
EPS (ttm)Profit attributable to each share over the last twelve months.
−1.96
Financials (FY)
Revenue (FY)
$0.00−100.00%
Net Income (FY)
−$137.06M
Profit marginThe share of revenue left as profit after all costs and taxes.
0.00%
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
94.67M
1-Year Return
+125.42%
Dividend and dates
Earnings Date
November 10, 2026estimated
Avg Volume
1.21M

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

ZNTL Stock Return by Calendar Year

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)+195.56%
2025−55.45%
2024−80.00%
2023−24.78%
2022−76.04%
2021+61.84%
2020 (partial year)+123.88%

As of September 4, 2026.

ZNTL Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$0.00−$137.06M—
2024$67.43M−$165.84M−246.0%
2023$0.00−$292.19M—
2022$0.00−$236.81M—
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$0.00—−$145.01M−$137.06M—
2024$67.43M—−$187.46M−$165.84M−246.0%
2023$0.00—−$253.94M−$292.19M—
2022$0.00—−$227.29M−$236.81M—

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

ZNTL Valuation vs Biotechnology Median

Median of 656 stocks
MetricZNTLBiotechnology medianvs median
Profit margin0.00%0.00%0.0 pts above

Medians across 656 Biotechnology stocks that report the metric. Medians, not averages, so one outlier cannot move them. As of September 4, 2026.

Recent News

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

Zentalis Pharmaceuticals, Inc. (ZNTL) carries a market capitalisation of $377.74M. It is classified in the Biotechnology industry, within the Healthcare sector. The company reports 106 employees.

The 52-week range on file runs from $1.21 to $6.95. ZNTL last closed at $3.99 on September 4, 2026. That is −$0.12 (−2.92%) against the previous close. The latest close sits 229.21% above that 52-week low.

Financial Health

The most recent full year on file, fiscal 2025, shows revenue of $0.00. Against the prior fiscal year total of $67.43M, that is a change of −100.00%. The same year closed with a net loss of $137.06M. Profit margin runs at 0%. Trailing earnings per share are −1.96.

Across the 4 fiscal years on file, revenue moves from $0.00 in 2022 to $0.00 in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

The record shows negative trailing earnings, so no price-to-earnings ratio is published.

Beta against the wider market is reported at 1.86. Annualized volatility over the trailing 6 years is 91.44%. The trailing one-year price return is +125.42%. Measured over 5 years, that is −43.00% a year compounded.

Growth & Income

The record shows no dividend for ZNTL.

2026 is still running; the price is +195.56% year to date. Across the complete calendar years on file, 2021 returned +61.84% and 2024 returned −80.00%. Of the 5 complete calendar years on file, 1 finished higher.

Peer Comparison

Zentalis Pharmaceuticals, Inc. (ZNTL) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Zentalis Pharmaceuticals, Inc. ZNTL $377.74M —
Vertex Pharmaceuticals Incorporated VRTX $138.42B 32.5
Regeneron Pharmaceuticals, Inc. REGN $85.22B 20.5
argenx SE ARGX $64.25B 40.1

The Biotechnology industry average P/E ratio is 12.6x. Zentalis Pharmaceuticals, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each nightly rebuild. Informational only, not financial advice. As of September 4, 2026.

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About Zentalis Pharmaceuticals, Inc.

Zentalis Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics for the treatment of various cancers in the United States. It develops azenosertib, which is in a Phase 3 clinical trial for the treatment of ovarian cancer and other tumor types. The company also develops ZN-c3-001, a phase 1 study that evaluated azenosertib monotherapy in solid tumors; and MAMMOTH (ZN-c3-006) is a Phase 1/2 clinical trial of azenosertib in patients with PARP-inhibitor resistant ovarian cancer. It has licensing agreements and strategic collaborations with Recurium IP Holdings, LLC. Zentalis Pharmaceuticals, Inc. was incorporated in 2014 and is based in San Diego, California.

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