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NASDAQ · Biotechnology · USD

Stoke Therapeutics, Inc. (STOK) Stock Analysis

Stoke Therapeutics, Inc. (STOK) is a Biotechnology stock listed on NASDAQ and quoted in US Dollar.

Last Updated: October 21, 2026

STOK

$25.68

−$0.93 (−3.49%)

Oct 21, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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STOK Key Statistics

As of Oct 21, 2026
Trading
Open
$26.83
Previous Close
$26.61
Day's Range
25.35–27.22
52-Week Range
20.32–40.22
Volume
2.26M
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
1.26
Valuation
Market Cap
$1.66B
P/E Ratio
unprofitable
P/S ratioMarket value divided by annual revenue. Useful for companies that are not yet profitable, where a P/E cannot be calculated.
60.06
EPS (ttm)Profit attributable to each share over the last twelve months.
−3.38
Financials (FY)
Revenue (FY)
$184.42M+404.50%
Net Income (FY)
−$6.89M
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
64.53M
1-Year Return
−25.95%
Dividend and dates
Earnings Date
November 3, 2026estimated
Avg Volume
908.25K

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

Key facts

As of October 21, 2026, STOK closed at $25.68, −25.95% over 1 year.

Stoke Therapeutics, Inc. (STOK) has a market capitalization of $1.66B.

In fiscal 2025, STOK reported revenue of $184.42M.

STOK Stock Return by Calendar Year

Stoke Therapeutics, Inc. (STOK) return since Jun 2019: what $10,000 became

1 year
$10,000 $7,405
−25.95%
5 years
$10,000 $11,055
+10.55%
Since Jun 2019
$10,000 $10,043
+0.43%

If you had invested $10,000 in Stoke Therapeutics, Inc. (STOK) at the close on June 19, 2019, the earliest close on record here, it would have been worth $10,043 at the close on October 21, 2026: +0.43% in total, +0.06% a year, over a partial period shorter than 10 years. A historical calculation from closing prices adjusted for splits and dividends, before fees and taxes.

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)−19.09%
2025+187.76%
2024+109.70%
2023−43.01%
2022−61.53%
2021−61.26%
2020+118.68%
2019 (partial year)+10.75%

As of October 21, 2026.

STOK Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$184.42M−$6.89M−3.7%
2024$36.56M−$88.98M−243.4%
2023$8.78M−$104.70M−1,192.5%
2022$12.41M−$101.07M−814.7%
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$184.42M—−$20.59M−$6.89M−3.7%
2024$36.56M—−$101.37M−$88.98M−243.4%
2023$8.78M—−$114.77M−$104.70M−1,192.5%
2022$12.41M—−$104.36M−$101.07M−814.7%

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

STOK Valuation vs Biotechnology Median

Median of 608 stocks
MetricSTOKBiotechnology medianvs median
P/S ratio60.0613.304.5x the median

Medians across 608 Biotechnology stocks that report the metric. Medians, not averages, so one outlier cannot move them. As of October 21, 2026.

Recent News

All 20 articles ↓

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

Stoke Therapeutics, Inc. (STOK) is capitalised at $1.66B on the latest close. It is classified in the Biotechnology industry, within the Healthcare sector. The company reports 170 employees.

The 52-week range on file runs from $20.32 to $40.22. The most recent close on file for STOK is $25.68, dated October 21, 2026. That is −$0.93 (−3.49%) against the previous close. The latest close sits 26.38% above that 52-week low.

Financial Health

Fiscal 2025 revenue came to $184.42M. That is +404.50% against the prior fiscal year, when revenue was $36.56M. The same year closed with a net loss of $6.89M. Trailing earnings per share are −3.38.

Across the 4 fiscal years on file, revenue moves from $12.41M in 2022 to $184.42M in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

No trailing P/E applies: the last reported earnings figure is negative. Measured against sales, the shares trade at 60.06 times revenue. On price-to-sales that is 4.5 times the Biotechnology median of 13.3. The medians here are taken across 608 Biotechnology companies that report the metric.

Beta against the wider market is reported at 1.26. Daily returns over the trailing 7 years annualize to a volatility of 79.38%. Over the trailing twelve months the total return is −25.95%. Across 5 years the annualized return works out at +2.03%.

Growth & Income

The record shows no dividend for STOK.

2026 is still running; the total return is −19.09% year to date. Across the complete calendar years on file, 2025 returned +187.76% and 2022 returned −61.53%. Of the 6 complete calendar years on file, 3 finished higher.

Peer Comparison

Stoke Therapeutics, Inc. (STOK) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Stoke Therapeutics, Inc. STOK $1.66B —
Vertex Pharmaceuticals Incorporated VRTX $132.95B 30.4
Moderna, Inc. MRNA $98.14B —
Regeneron Pharmaceuticals, Inc. REGN $82.95B 19.9

The Biotechnology industry average P/E ratio is 16.6x. Stoke Therapeutics, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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About Stoke Therapeutics, Inc.

Stoke Therapeutics, Inc. engages in the development of treatments for severe genetic diseases by upregulating protein expression. The company utilizes its proprietary Targeted Augmentation of Nuclear Gene Output (TANGO) approach in developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Its lead product candidates include STK-002, which is in Phase 1 clinical trials for the treatment of autosomal dominant optic atrophy; and Zorevunersen (STK-001), an investigational new medicine for the treatment of Dravet syndrome is being evaluated in phase 3 clinical trials. The company also develops programs focused on various targets, including haploinsufficiency diseases of the central nervous system and eye. It has a license and collaboration with Biogen Inc. for the development and commercialization of zorevunersen medicine for the treatment of Dravet syndrome; and Acadia Pharmaceuticals Inc. for the discovery, development, and commercialization of novel RNA-based medicines for the treatment of genetic neurodevelopmental diseases. The company was formerly known as ASOthera Pharmaceuticals, Inc. and changed its name to Stoke Therapeutics, Inc. in May 2016. Stoke Therapeutics, Inc. was incorporated in 2014 and is headquartered in Bedford, Massachusetts.

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