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Personalis, Inc. (PSNL) Stock Analysis

Healthcare

Personalis, Inc.

$8.94

+$0.47 (+5.55%)

Last Updated: May 26, 2026

Price History

Analysis

Company Overview

Personalis, Inc. operates within the healthcare sector, specifically focusing on diagnostics and research, where it develops, markets, and sells advanced cancer genomic tests and services across the United States and international markets. The company's core product offering includes NeXT Personal, a tumor-informed liquid biopsy test designed for the detection of minimal residual disease, therapy response, and recurrence monitoring. In terms of scale, the company currently holds a market capitalization of $797.29M and generates annual revenue of $69.65M based on trailing twelve-month data. With an employee base of 259, the organization maintains a relatively compact workforce to support its specialized genomic testing operations. The market cap figure of $797.29M combined with the annual revenue of $69.65M indicates that the market values the company at a multiple significantly higher than its current revenue generation, reflecting high expectations for future expansion or the strategic importance of its diagnostic technology within the broader genomic medicine landscape.

Financial Health

The company reported a revenue of $69.65M for the trailing twelve months, yet it recorded a net income of -$81,270,000, revealing a significant gap where operating expenses substantially exceeded total revenue. This negative net income is further compounded by an EBITDA of -$78,011,000, which suggests that core business operations are currently generating losses before financing and non-cash items. Free cash flow stands at -$42,980,752, indicating that the company is burning cash at a rate that must be covered by existing cash reserves or external financing to maintain liquidity. Margins across the board reflect this financial pressure, with a gross margin of 22.7% showing that production costs consume the majority of revenue, while an operating margin of -145.7% and a profit margin of -116.7% highlight severe inefficiencies or high investment costs relative to sales. The balance sheet shows a cash position of $239.95M against total debt of $44.01M, resulting in a debt-to-equity ratio of 16.85, which indicates a conservative leverage structure despite the lack of profitability. Additionally, the current ratio is 6.76, signaling strong short-term liquidity as current assets are more than six times current liabilities. Return on equity is -35.0% and return on assets is -18.2%, metrics that reveal management is currently destroying shareholder value and utilizing assets to generate negative returns rather than positive economic profit.

Valuation Assessment

Valuation metrics for Personalis present a complex picture given the company's unprofitable status, with a trailing P/E ratio of N/A and a forward P/E of -8.16. The negative forward P/E implies that the market is pricing in a future trajectory where earnings are expected to remain negative or that traditional earnings-based valuation methods are not applicable at this stage. The price-to-book ratio is 2.99, suggesting that the stock trades at a significant premium of nearly three times its book value, which may reflect investor confidence in intangible assets like intellectual property or future growth potential rather than current earnings. Alternative valuation multiples such as the price-to-sales ratio of 11.45 and an EV/EBITDA of -7.23 further illustrate that investors are valuing the company primarily on its revenue scale rather than profitability. The stock has traded between a 52-week high of $11.50 and a 52-week low of $2.83, with the current market capitalization implying a valuation that sits well above the 52-week low, indicating significant volatility and a wide trading range over the last year. The beta value of 2.11 indicates that the stock is highly volatile, moving with more than twice the magnitude of the broader market, which introduces substantial price risk for holders seeking stability.

Growth & Income

Revenue growth over the last year stands at 3.2%, while earnings growth is listed as N/A due to the company's persistent net losses. Since there are no positive earnings, the comparison between revenue and earnings growth is not applicable in a traditional sense, as the company is not yet generating the profits required to sustain positive earnings growth rates. Consequently, the company does not pay dividends, evidenced by a dividend yield of N/A and a payout ratio of 0.0%, meaning all available cash and future earnings potential are theoretically reinvested into growth initiatives rather than distributed to shareholders. The overall growth and income profile is characterized by modest revenue expansion paired with significant cash burn and a complete absence of dividend income, positioning the company as a high-risk, high-revenue-growth play dependent on future profitability to sustain operations.

Peer Comparison

Personalis, Inc. (PSNL) operates in the Diagnostics & Research industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Personalis, Inc. PSNL $936.21M N/A
Thermo Fisher Scientific Inc. TMO $166.55B 24.6
Danaher Corporation DHR $122.31B 33.4
IDEXX Laboratories, Inc. IDXX $43.95B 41.0

The Diagnostics & Research industry average P/E ratio is 32.5x. Personalis, Inc. trades at a P/E of N/A.

This analysis is AI-generated for informational purposes only and should not be considered financial advice. Data may be delayed or inaccurate. Always do your own research and consult a qualified financial advisor before making investment decisions.

About Personalis, Inc.

Personalis, Inc. develops, markets, and sells advanced cancer genomic tests and services in the United States and internationally. The company offers NeXT Personal, a tumor-informed liquid biopsy test for detection of minimal residual disease (MRD), therapy response and recurrence monitoring in solid tumor cancers; and ImmunoID NeXT, a tissue-based service that combines whole exome and whole transcriptome sequencing data with advanced analytics to provide a multi-dimensional view of the tumor and the tumor microenvironment from a single sample. It also provides NeXT Personal Dx, a tumor-informed liquid biopsy test for the detection of MRD; and NeXT Dx, a tumor profiling test that is used to help select therapy for a cancer patient and identify potential clinical trials for a patient. In addition, the company performs whole exome sequencing of cancer tissue and matched blood samples for diagnostic companies as an input to their products; and whole genome sequencing on human samples for research projects, such as population sequencing initiatives. Its services are used by pharmaceutical companies for translational research, biomarker discovery, the development of personalized cancer therapies, and for clinical trials, as well as tests are used by physicians to detect residual or recurrent cancer in patients, monitor cancer response to therapy, and uncover insights for therapy selection. The company's customers include pharmaceutical companies, biopharmaceutical companies, diagnostics companies, universities, non-profits, government entities, and cancer patients. The company has strategic collaboration with Tempus AI, Inc. to bring testing to colorectal cancer patients. Personalis, Inc. was incorporated in 2011 and is headquartered in Fremont, California.

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Key Statistics

Market Cap
$936.21M
P/E Ratio
N/A
52-Week High
$11.50
52-Week Low
$3.84
Avg Volume
1.98M
Beta
1.97

Data provided by Yahoo Finance via yfinance. Updated daily.

Company Info

Exchange
NASDAQ
Country
United States
Employees
259