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NASDAQ · Diagnostics & Research · USD

Personalis, Inc. (PSNL) Stock Analysis

Personalis, Inc. (PSNL) is a Diagnostics & Research stock listed on NASDAQ and quoted in US Dollar.

PSNL

$17.20

+$0.37 (+2.20%)

Sep 4, 2026 · Market close

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Price History

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PSNL Key Statistics

As of Sep 4, 2026
Trading
Open
$16.67
Previous Close
$16.83
Day's Range
16.52–17.23
52-Week Range
4.96–18.89
Volume
2.52M
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
2.32
Valuation
Market Cap
$1.84B
P/E Ratio
unprofitable
P/S ratioMarket value divided by annual revenue. Useful for companies that are not yet profitable, where a P/E cannot be calculated.
26.37
EPS (ttm)Profit attributable to each share over the last twelve months.
−1.09
Financials (FY)
Revenue (FY)
$69.65M−17.69%
Net Income (FY)
−$81.27M
Profit marginThe share of revenue left as profit after all costs and taxes.
−153.84%
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
106.80M
1-Year Return
+237.92%
Dividend and dates
Earnings Date
November 3, 2026estimated
Avg Volume
4.14M

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

PSNL Stock Return by Calendar Year

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)+116.08%
2025+37.72%
2024+175.24%
2023+6.06%
2022−86.12%
2021−61.02%
2020+235.87%
2019 (partial year)−61.74%

As of September 4, 2026.

PSNL Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$69.65M−$81.27M−116.7%
2024$84.61M−$81.28M−96.1%
2023$73.48M−$108.30M−147.4%
2022$65.05M−$113.32M−174.2%
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$69.65M$15.78M−$88.06M−$81.27M−116.7%
2024$84.61M$26.83M−$68.27M−$81.28M−96.1%
2023$73.48M$18.21M−$96.29M−$108.30M−147.4%
2022$65.05M$13.35M−$115.53M−$113.32M−174.2%

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

PSNL Valuation vs Diagnostics & Research Median

Median of 49 stocks
MetricPSNLDiagnostics & Research medianvs median
P/S ratio26.374.995.3x the median
Profit margin−153.84%0.00%153.8 pts below

Medians across 49 Diagnostics & Research stocks that report the metric. Medians, not averages, so one outlier cannot move them. As of September 4, 2026.

Recent News

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

The market values Personalis, Inc. (PSNL) at $1.84B. It is classified in the Diagnostics & Research industry, within the Healthcare sector. Headcount on file is 259.

The 52-week range on file runs from $4.96 to $18.89. The most recent close on file for PSNL is $17.20, dated September 4, 2026. That is +$0.37 (+2.20%) against the previous close. The latest close sits 247.12% above that 52-week low.

Financial Health

The most recent full year on file, fiscal 2025, shows revenue of $69.65M. Against the prior fiscal year total of $84.61M, that is a change of −17.69%. The same year closed with a net loss of $81.27M. The reported profit margin is −153.84%. That is 153.8 percentage points below the Diagnostics & Research median of 0%. Earnings per share on a trailing basis come to −1.09.

Across the 4 fiscal years on file, revenue moves from $65.05M in 2022 to $69.65M in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

No trailing P/E applies: the last reported earnings figure is negative. The price-to-sales ratio is 26.37. On price-to-sales that is 5.3 times the Diagnostics & Research median of 4.99. The medians here are taken across 49 Diagnostics & Research companies that report the metric.

Over the trailing twelve months the price has returned +237.92%. Across 5 years the annualized return works out at −5.17%. The reported beta is 2.32. Daily returns over the trailing 7 years annualize to a volatility of 97.54%.

Growth & Income

The record shows no dividend for PSNL.

Across the complete calendar years on file, 2020 returned +235.87% and 2022 returned −86.12%. Of the 6 complete calendar years on file, 4 finished higher. 2026 is still running; the price is +116.08% year to date.

Peer Comparison

Personalis, Inc. (PSNL) operates in the Diagnostics & Research industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Personalis, Inc. PSNL $1.84B
Thermo Fisher Scientific Inc. TMO $226.94B 33.0
Danaher Corporation DHR $145.98B 37.0
Natera, Inc. NTRA $47.31B

The Diagnostics & Research industry average P/E ratio is 33.1x. Personalis, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each nightly rebuild. Informational only, not financial advice. As of September 4, 2026.

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About Personalis, Inc.

Personalis, Inc. develops, markets, and sells advanced cancer genomic tests and services in the United States and internationally. The company offers NeXT Personal, a tumor-informed liquid biopsy test for detection of minimal residual disease (MRD), therapy response and recurrence monitoring in solid tumor cancers; and ImmunoID NeXT, a tissue-based service that combines whole exome and whole transcriptome sequencing data with advanced analytics to provide a multi-dimensional view of the tumor and the tumor microenvironment from a single sample. It also provides NeXT Personal Dx, a tumor-informed liquid biopsy test for the detection of MRD; and NeXT Dx, a tumor profiling test that is used to help select therapy for a cancer patient and identify potential clinical trials for a patient. In addition, the company performs whole exome sequencing of cancer tissue and matched blood samples for diagnostic companies as an input to their products; and whole genome sequencing on human samples for research projects, such as population sequencing initiatives. Its services are used by pharmaceutical companies for translational research, biomarker discovery, the development of personalized cancer therapies, and for clinical trials, as well as tests are used by physicians to detect residual or recurrent cancer in patients, monitor cancer response to therapy, and uncover insights for therapy selection. The company's customers include pharmaceutical companies, biopharmaceutical companies, diagnostics companies, universities, non-profits, government entities, and cancer patients. The company has strategic collaboration with Tempus AI, Inc. to bring testing to colorectal cancer patients. Personalis, Inc. was incorporated in 2011 and is headquartered in Fremont, California.

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