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NASDAQ · Biotechnology · USD

NuCana plc (NCNA) Stock Analysis

NuCana plc (NCNA) is a Biotechnology stock listed on NASDAQ and quoted in US Dollar.

Last Updated: October 21, 2026

NCNA

$0.96

−$0.04 (−4.33%)

Oct 21, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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NCNA Key Statistics

As of Oct 21, 2026
Trading
Open
$1.00
Previous Close
$1.01
Day's Range
0.96–1.01
52-Week Range
0.95–4.55
Volume
29.62K
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
2.31
Valuation
Market Cap
$4.00M
EPS (ttm)Profit attributable to each share over the last twelve months.
0.00
Financials (FY)
Revenue (FY)
$0.00
Net Income (FY)
−$29.35M
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
4.16M
1-Year Return
−77.15%
Dividend and dates
Avg Volume
119.68K

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

Key facts

As of October 21, 2026, NCNA closed at $0.96, −77.15% over 1 year.

NuCana plc (NCNA) has a market capitalization of $4.00M.

In fiscal 2025, NCNA reported revenue of $0.00.

NCNA Stock Return by Calendar Year

NuCana plc (NCNA) return since Sep 2017: what $10,000 became

1 year
$10,000 $2,285
−77.15%
5 years
$10,000 $0.75
−99.99%
Since Sep 2017
$10,000 $0.12
−99.999%

If you had invested $10,000 in NuCana plc (NCNA) at the close on September 28, 2017, the earliest close on record here, it would have been worth $0.12 at the close on October 21, 2026: −99.999% in total, −71.38% a year, over a partial period shorter than 10 years. A historical calculation from closing prices adjusted for splits and dividends, before fees and taxes.

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)−73.28%
2025−98.49%
2024−83.92%
2023−55.15%
2022−72.27%
2021−46.99%
2020−26.39%
2019−57.93%
2018+43.42%
2017 (partial year)−37.40%

As of October 21, 2026.

NCNA Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$0.00−$29.35M—
2024$0.00−$19.00M—
2023$0.00−$27.63M—
2022$0.00−$32.02M—
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$0.00—−$20.83M−$29.35M—
2024$0.00—−$23.01M−$19.00M—
2023$0.00—−$31.13M−$27.63M—
2022$0.00—−$43.72M−$32.02M—

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

Recent News

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

The market values NuCana plc (NCNA) at $4.00M. The company sits in the Healthcare sector, in the Biotechnology industry. The company reports 10 employees.

NCNA last closed at $0.96 on October 21, 2026. That is −$0.04 (−4.33%) against the previous close. Over the past 52 weeks the price has ranged from $0.95 to $4.55. The latest close sits 1.49% above that 52-week low.

Financial Health

The most recent full year on file, fiscal 2025, shows revenue of $0.00. The same year closed with a net loss of $29.35M. Earnings per share on a trailing basis come to 0.

Across the 4 fiscal years on file, revenue moves from $0.00 in 2022 to $0.00 in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

Beta against the wider market is reported at 2.31. Daily returns over the trailing 9 years annualize to a volatility of 147.27%. Over the trailing twelve months the total return is −77.15%. Across 5 years the annualized return works out at −85.04%.

Growth & Income

No dividend is on file for NCNA.

2026 is still running; the total return is −73.28% year to date. Across the complete calendar years on file, 2018 returned +43.42% and 2025 returned −98.49%. Of the 8 complete calendar years on file, 1 finished higher.

Peer Comparison

NuCana plc (NCNA) operates in the Biotechnology industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
NuCana plc NCNA $4.00M —
Vertex Pharmaceuticals Incorporated VRTX $132.95B 30.4
Moderna, Inc. MRNA $98.14B —
Regeneron Pharmaceuticals, Inc. REGN $82.95B 19.9

The Biotechnology industry average P/E ratio is 16.6x. NuCana plc has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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About NuCana plc

NuCana plc, a clinical-stage biopharmaceutical company, engages in the development of medicines to treat patients with cancer in the United States. It applies its ProTide technology to transform prescribed chemotherapy agents and nucleoside analogs into medicines. The company is developing medicines to overcome the limitations of nucleoside analogs and generate concentrations of anti-cancer metabolites in cancer cells. Its pipeline includes NUC-3373, a chemical entity derived from the nucleoside analog 5-fluorouracil that is in Phase 1b/2 study in patients with metastatic colorectal cancer; Phase 2 clinical trial for the second-line treatment of patients with advanced colorectal cancer; and Phase 1b/2 modular clinical trial for patients with advanced solid tumors and lung cancer. It also developing NUC-7738, a ProTide transformation of 3'-deoxyadenosine, which is in the Phase 2 part of a Phase 1/2 clinical trial for patients with advanced solid tumors. It has an assignment, license, and collaboration agreement with Cardiff ProTides Ltd to discover, drug design, and in vitro screen purine and pyrimidine-based nucleosides as potential drug candidates. The company was formerly known as NuCana BioMed Limited and changed its name to NuCana plc in August 2017. NuCana plc was incorporated in 1997 and is based in Edinburgh, the United Kingdom.

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