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NYSE Arca · Health · USD · ETF

State Street SPDR S&P Biotech ETF (XBI) ETF Analysis

XBI
Expense ratio 0.35% Yield 0.35% Assets $10.36B Since January 31, 2006 Family State Street Investment Management

Last Updated: October 21, 2026

$152.78
−$0.46 (−0.30%)

October 21, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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XBI Annualized Returns

PeriodAnnualized$100 becomes
1 year+40.05%$140.05
3 years+31.95%$229.75
5 years+4.42%$124.15
10 years+10.00%$259.37

Returns are total returns computed from daily closes, with dividends reinvested. As of October 21, 2026.

XBI Return by Calendar Year

2016 and 2026 are partial years

View as table ↓View as chart ↑
YearReturn
2026 (partial year)+25.42%
2025+35.89%
2024+1.01%
2023+7.60%
2022−25.87%
2021−20.45%
2020+48.33%
2019+32.56%
2018−15.28%
2017+43.77%
2016 (partial year)−5.95%

XBI Monthly Returns

−18%+21%
YearJanFebMarAprMayJunJulAugSepOctNovDec
2026+2.3+2.1+0.3+2.8+4.1+15.9−7.1+10.5−3.0−3.1——
2025+2.9−4.3−8.6+2.3−4.5+4.7+3.3+4.9+11.6+12.5+9.3−0.7
2024−2.1+12.6−3.6−10.8+5.3+4.1+6.8+2.2−2.4−1.8+2.7−9.6
2023+7.1−6.8−8.0+5.2+4.6−0.9+1.3−6.0−7.8−9.3+14.0+18.3
2022−16.6−3.9+0.1−17.9−6.8+8.0+9.2+3.2−5.2+3.6+1.8−0.7
2021+8.6−3.2−8.3+0.7−6.2+5.7−8.9+7.6−5.4−0.7−6.8−3.7
2020−6.3+0.1−13.2+20.6+10.9+8.1−2.3+2.3−0.3+1.2+18.1+5.8
2019+16.5+6.6+1.6−5.9−6.8+10.4−2.3−6.2−5.1+7.1+14.7+1.6
2018+10.0−3.2−2.8−0.9+8.8+0.6+0.1+5.1−4.2−17.5+3.2−12.1
2017+9.6+8.2−1.2+3.0−5.2+14.2+1.3+7.2+3.3−3.4−0.5+2.1

Monthly total returns with dividends reinvested; each cell prints its signed value.

XBI Volatility & Risk

Volatility: 10 yrs · Beta: 3 yrs
Annualized volatility
31.97%
Beta (3y)
1.09
Best year
+48.33%

2020

Worst year
−25.87%

2022

Volatility is the annualized standard deviation of daily returns. As of October 21, 2026.

Recent News

News provided by third-party sources. Not financial advice.

Top Holdings

# Symbol Name Weight
1 TWST Twist Bioscience Corp 2.21%
2 MRNA Moderna Inc 2.04%
3 NTRA Natera Inc 1.8%
4 IOVA Iovance Biotherapeutics Inc 1.62%
5 AMGN Amgen Inc 1.55%
6 BIIB Biogen Inc 1.54%
7 UTHR United Therapeutics Corp 1.54%
8 ABBV AbbVie Inc 1.5%
9 HALO Halozyme Therapeutics Inc 1.48%
10 SYRE Spyre Therapeutics Inc 1.47%

Analysis

Data-derived

Fund Overview

State Street SPDR S&P Biotech ETF (XBI) is an exchange-traded fund in the Health category. Total net assets stand at $10.36B. Annual costs run at an expense ratio of 0.35%. On a $10,000 position that is $35.00 a year. State Street Investment Management is the fund family on file. It has been trading since January 31, 2006.

Its biggest positions are Twist Bioscience Corp (TWST), Moderna Inc (MRNA), and Natera Inc (NTRA). Twist Bioscience Corp alone accounts for 2.21% of the portfolio. The ten largest positions together make up 16.73% of the fund.

Performance Analysis

XBI last closed at $152.78 on October 21, 2026. The trailing one-year total return is +40.05%. Measured over 10 years, that is +10.00% a year compounded. The trailing distribution yield is 0.35%.

Across the complete calendar years on file, 2020 returned +48.33% and 2022 returned −25.87%. Of the 9 complete calendar years on file, 6 finished higher. 2026 is still running; the total return is +25.42% year to date.

Price & Risk Profile

Daily returns over the trailing 10 years annualize to a volatility of 31.97%. The reported beta is 1.09. Over the past 52 weeks the price has ranged from $106.30 to $169.89. The latest close sits 43.73% above that 52-week low. The volatility figure is calculated from the stored daily closes, the same series the charts on this page use.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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