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NASDAQ · Drug Manufacturers - Specialty & Generic · USD

Xeris Biopharma Holdings, Inc. (XERS) Stock Analysis

Xeris Biopharma Holdings, Inc. (XERS) is a Drug Manufacturers - Specialty & Generic stock listed on NASDAQ and quoted in US Dollar.

Last Updated: October 21, 2026

XERS

$10.79

−$0.35 (−3.10%)

Oct 21, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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XERS Key Statistics

As of Oct 21, 2026
Trading
Open
$11.14
Previous Close
$11.13
Day's Range
10.77–11.28
52-Week Range
5.25–11.42
Volume
1.68M
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
0.84
Valuation
Market Cap
$1.97B
P/E Ratio
unprofitable
Forward P/EShare price divided by forecast earnings for the year ahead, rather than the year just past.
29.15
P/S ratioMarket value divided by annual revenue. Useful for companies that are not yet profitable, where a P/E cannot be calculated.
5.86
EPS (ttm)Profit attributable to each share over the last twelve months.
−0.10
Financials (FY)
Revenue (FY)
$291.85M+43.72%
Net Income (FY)
$554.00K
Profit marginThe share of revenue left as profit after all costs and taxes.
−5.12%
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
182.32M
1-Year Return
+18.78%
Dividend and dates
Earnings Date
November 5, 2026
Avg Volume
2.31M

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

Key facts

As of October 21, 2026, XERS closed at $10.79, +18.78% over 1 year.

Xeris Biopharma Holdings, Inc. (XERS) has a market capitalization of $1.97B.

In fiscal 2025, XERS reported revenue of $291.85M.

XERS Stock Return by Calendar Year

Xeris Biopharma Holdings, Inc. (XERS) return since Jun 2018: what $10,000 became

1 year
$10,000 $11,878
+18.78%
5 years
$10,000 $54,746
+447.46%
Since Jun 2018
$10,000 $5,334
−46.66%

If you had invested $10,000 in Xeris Biopharma Holdings, Inc. (XERS) at the close on June 21, 2018, the earliest close on record here, it would have been worth $5,334 at the close on October 21, 2026: −46.66% in total, −7.26% a year, over a partial period shorter than 10 years. A historical calculation from closing prices adjusted for splits and dividends, before fees and taxes.

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)+37.39%
2025+131.56%
2024+44.26%
2023+76.69%
2022−54.61%
2021−40.45%
2020−30.21%
2019−58.53%
2018 (partial year)−15.92%

As of October 21, 2026.

XERS Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$291.85M$554.00K0.2%
2024$203.07M−$54.84M−27.0%
2023$163.91M−$62.26M−38.0%
2022$110.25M−$94.66M−85.9%
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$291.85M$249.28M$24.90M$554.00K0.2%
2024$203.07M$166.24M−$33.65M−$54.84M−27.0%
2023$163.91M$135.27M−$44.01M−$62.26M−38.0%
2022$110.25M$87.61M−$81.94M−$94.66M−85.9%

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

XERS Valuation vs Drug Manufacturers - Specialty & Generic Median

Median of 97 stocks
MetricXERSDrug Manufacturers - Specialty & Generic medianvs median
P/S ratio5.862.10179% above
Profit margin−5.12%−8.14%3.0 pts above

Medians across 97 Drug Manufacturers - Specialty & Generic stocks that report the metric. Medians, not averages, so one outlier cannot move them. As of October 21, 2026.

Recent News

All 19 articles ↓

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

Xeris Biopharma Holdings, Inc. (XERS) is capitalised at $1.97B on the latest close. The company sits in the Healthcare sector, in the Drug Manufacturers - Specialty & Generic industry. Headcount on file is 435.

The most recent close on file for XERS is $10.79, dated October 21, 2026. That is −$0.35 (−3.10%) against the previous close. Over the past 52 weeks the price has ranged from $5.25 to $11.42. The latest close sits 105.43% above that 52-week low.

Financial Health

In fiscal 2025, Xeris Biopharma Holdings, Inc. reported revenue of $291.85M. Against the prior fiscal year total of $203.07M, that is a change of +43.72%. Net income for the same year was $554.00K. The reported profit margin is −5.12%. That is 3 percentage points above the Drug Manufacturers - Specialty & Generic median of −8.14%. Earnings per share on a trailing basis come to −0.1.

Across the 4 fiscal years on file, revenue moves from $110.25M in 2022 to $291.85M in 2025. Of those 4 years, 1 report positive net income.

Valuation Assessment

The record shows negative trailing earnings, so no price-to-earnings ratio is published. The forward P/E on file is 29.15. The price-to-sales ratio is 5.86. On price-to-sales that is 179.17% above the Drug Manufacturers - Specialty & Generic median of 2.1. The medians here are taken across 97 Drug Manufacturers - Specialty & Generic companies that report the metric.

The reported beta is 0.84. Annualized volatility over the trailing 8 years is 78.49%. Over the trailing twelve months the total return is +18.78%. Measured over 5 years, that is +40.50% a year compounded.

Growth & Income

The record shows no dividend for XERS.

2026 is still running; the total return is +37.39% year to date. Across the complete calendar years on file, 2025 returned +131.56% and 2019 returned −58.53%. Of the 7 complete calendar years on file, 3 finished higher.

Peer Comparison

Xeris Biopharma Holdings, Inc. (XERS) operates in the Drug Manufacturers - Specialty & Generic industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
Xeris Biopharma Holdings, Inc. XERS $1.97B —
Takeda Pharmaceutical Company Limited TAK $63.67B —
Teva Pharmaceutical Industries Limited TEVA $47.37B 67.7
Haleon plc HLN $44.06B 20.5

The Drug Manufacturers - Specialty & Generic industry average P/E ratio is 20.3x. Xeris Biopharma Holdings, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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About Xeris Biopharma Holdings, Inc.

Xeris Biopharma Holdings, Inc., a commercial-stage biopharmaceutical company, engages in developing and commercializing therapies for chronic endocrine and neurological diseases in Illinois. It offers Gvoke, a ready-to-use liquid-stable glucagon for the treatment of severe hypoglycemia in pediatric and adult patients; Keveyis, a therapy for the treatment of hyperkalemic, hypokalemic, and related variants of primary periodic paralysis; and Recorlev, a cortisol synthesis inhibitor for the treatment of endogenous hypercortisolemia in adult patients with Cushing's syndrome. It is also developing XP-8121, a once-weekly subcutaneous injection of levothyroxine that is in phase 3 clinical trial for the treatment of hypothyroidism. The company was incorporated in 2005 and is headquartered in Chicago, Illinois.

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