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StockVS

NASDAQ · Diagnostics & Research · USD

OPKO Health, Inc. (OPK) Stock Analysis

OPKO Health, Inc. (OPK) is a Diagnostics & Research stock listed on NASDAQ and quoted in US Dollar.

Last Updated: October 21, 2026

OPK

$1.60

−$0.06 (−3.61%)

Oct 21, 2026 · Market close

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Price History

Hover for the daily close. The dotted line marks the period open.

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OPK Key Statistics

As of Oct 21, 2026
Trading
Open
$1.66
Previous Close
$1.66
Day's Range
1.60–1.66
52-Week Range
0.98–1.77
Volume
2.48M
BetaHow much the share price moves relative to the wider market. 1.0 moves in line with it; above 1.0 swings more, below 1.0 less.
1.50
Valuation
Market Cap
$1.19B
P/E Ratio
unprofitable
PEG RatioThe P/E ratio divided by the expected earnings growth rate. It puts a high P/E in the context of how fast profits are growing.
93.65
P/S ratioMarket value divided by annual revenue. Useful for companies that are not yet profitable, where a P/E cannot be calculated.
2.03
EPS (ttm)Profit attributable to each share over the last twelve months.
−0.09
Financials (FY)
Revenue (FY)
$606.88M−14.90%
Net Income (FY)
−$225.68M
Profit marginThe share of revenue left as profit after all costs and taxes.
−12.40%
Shares OutstandingThe total number of shares held by all investors. Market value is this figure multiplied by the share price.
746.33M
1-Year Return
+8.11%
Dividend and dates
Earnings Date
October 28, 2026estimated
Avg Volume
4.26M

Only metrics the company reports are shown. Data provided by Yahoo Finance via yfinance. Updated daily.

Key facts

As of October 21, 2026, OPK closed at $1.60, +8.11% over 1 year.

OPKO Health, Inc. (OPK) has a market capitalization of $1.19B.

In fiscal 2025, OPK reported revenue of $606.88M.

OPK Stock Return by Calendar Year

OPKO Health, Inc. (OPK) 10-year return: what $10,000 became

1 year
$10,000 $10,811
+8.11%
5 years
$10,000 $4,324
−56.76%
10 years
$10,000 $1,704
−82.96%

If you had invested $10,000 in OPKO Health, Inc. (OPK) 10 years ago, at the close on October 21, 2016, it would have been worth $1,704 at the close on October 21, 2026: −82.96% in total, −16.22% a year. A historical calculation from closing prices adjusted for splits and dividends, before fees and taxes.

Calendar-year returns computed from daily closing prices. Partial years are shown muted and marked with an asterisk.

YearReturn
2026 (partial year)+26.98%
2025−14.29%
2024−2.65%
2023+20.80%
2022−74.01%
2021+21.77%
2020+168.71%
2019−51.16%
2018−38.57%
2017−47.31%
2016 (partial year)−8.01%

As of October 21, 2026.

OPK Revenue and Earnings by Fiscal Year

FY ends December
Fiscal yearRevenueNet incomeNet margin
2025$606.88M−$225.68M−37.2%
2024$713.14M−$53.22M−7.5%
2023$863.50M−$188.86M−21.9%
2022$1.00B−$328.41M−32.7%
Fiscal yearRevenueGross profitOperating incomeNet incomeNet margin
2025$606.88M$205.94M−$117.41M−$225.68M−37.2%
2024$713.14M$218.51M−$152.07M−$53.22M−7.5%
2023$863.50M$318.13M−$157.02M−$188.86M−21.9%
2022$1.00B$288.22M−$226.25M−$328.41M−32.7%

Annual figures as reported, in the company's reporting currency. As of December 31, 2025.

OPK Valuation vs Diagnostics & Research Median

Median of 45 stocks
MetricOPKDiagnostics & Research medianvs median
P/S ratio2.035.2361% below
Profit margin−12.40%−0.93%11.5 pts below

Medians across 45 Diagnostics & Research stocks that report the metric. Medians, not averages, so one outlier cannot move them. As of October 21, 2026.

Recent News

All 20 articles ↓

News provided by third-party sources. Not financial advice.

Analysis

Data-derived

Company Overview

OPKO Health, Inc. (OPK) carries a market capitalisation of $1.19B. The company sits in the Healthcare sector, in the Diagnostics & Research industry. Headcount on file is 2,275.

Over the past 52 weeks the price has ranged from $0.98 to $1.77. OPK last closed at $1.60 on October 21, 2026. That is −$0.06 (−3.61%) against the previous close. The latest close sits 63.27% above that 52-week low.

Financial Health

The most recent full year on file, fiscal 2025, shows revenue of $606.88M. That is −14.90% against the prior fiscal year, when revenue was $713.14M. The same year closed with a net loss of $225.68M. The reported profit margin is −12.4%. That is 11.5 percentage points below the Diagnostics & Research median of −0.93%. Trailing earnings per share are −0.09.

Across the 4 fiscal years on file, revenue moves from $1.00B in 2022 to $606.88M in 2025. Of those 4 years, 0 report positive net income.

Valuation Assessment

The record shows negative trailing earnings, so no price-to-earnings ratio is published. The PEG ratio, which sets the P/E against expected earnings growth, reads 93.65. Measured against sales, the shares trade at 2.03 times revenue. On price-to-sales that is 61.14% below the Diagnostics & Research median of 5.23. 45 Diagnostics & Research companies report these metrics, and the medians quoted come from that group.

The reported beta is 1.5. Annualized volatility over the trailing 10 years is 66.36%. Over the trailing twelve months the total return is +8.11%. Across 10 years the annualized return works out at −16.22%.

Growth & Income

No dividend is on file for OPK.

So far in 2026 the total return is +26.98%. Across the complete calendar years on file, 2020 returned +168.71% and 2022 returned −74.01%. Of the 9 complete calendar years on file, 3 finished higher.

Peer Comparison

OPKO Health, Inc. (OPK) operates in the Diagnostics & Research industry. Here is how it compares to its closest peers by market capitalization:

Company Ticker Market Cap P/E Ratio
OPKO Health, Inc. OPK $1.19B —
Thermo Fisher Scientific Inc. TMO $256.61B 37.4
Danaher Corporation DHR $164.40B 41.7
Natera, Inc. NTRA $59.59B —

The Diagnostics & Research industry average P/E ratio is 37.6x. OPKO Health, Inc. has no P/E ratio because it is not currently profitable.

Every figure above is read from this page's own data on each daily rebuild. Informational only, not financial advice. As of October 21, 2026.

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About OPKO Health, Inc.

OPKO Health, Inc. operates as a healthcare company, in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally. The company operates in two segments, Pharmaceutical and Diagnostics. The Pharmaceutical segment develops MDX2001, a tetra-specific antibody targeting several types of solid tumors in Phase 1 clinical trials; MDX2003, a tetra-specific antibody targeting two antigens for hematological tumors in Phase 1 clinical trials; and MDX2004, a trispecific immune modulator to rebuild and sustain the patient's own immune system. This segment also engages in the development of Epstein Barr Virus vaccine; Rayaldee, a patented extended-release product for oral administration containing 30 mcg of a prohormone; OPK-88006 oral and injectable product to regulate blood glucose and reduce body weight; NGENLA, recombinant human growth hormone product developed for the long-term treatment of pediatric patients with growth hormone deficiency. The Diagnostics segment offers laboratory testing services, such as detection, diagnosis, evaluation, monitoring, and treatment of diseases, as well as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare under the BioReference brand; and 4Kscore test. OPKO Health, Inc. was founded in 2006 and is headquartered in Miami, Florida.

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